• From Chromatin Mechanisms to Clinical Translation: Strate...

  2025-10-16

  This thought-leadership article distills mechanistic insight and strategic guidance for translational researchers, spotlighting the Hematoxylin and Eosin (H&E) Staining Kit as a linchpin for robust tissue morphology visualization. Bridging advances in chromatin biology—such as the essential role of KDM4A in malignant pleural mesothelioma—with experimental validation and workflow strategy, the piece delivers a forward-looking framework for leveraging histopathological staining in biomarker discovery, therapeutic innovation, and clinical impact.

• ApoBrdU DNA Fragmentation Assay Kit mg Plant material and gr

  2023-07-06

  

  Plant material and growth conditions. Arabidopsis thaliana ecotype Columbia was grown on a mixture of soil, vermiculite, and perlite (4:2:1) with a 16h light/8h dark ApoBrdU DNA Fragmentation Assay Kit mg in a temperature-controlled growth room (22°C), unless indicated otherwise. Molecular cloning

• Methylprednisolone br LOX in esophageal cancer Various

  2023-07-06

  

  5-LOX in esophageal cancer Various studies suggest that abnormal levels of AA metabolites play an essential role in human esophageal adenocarcinogenesis (EAC). The key AA derivatives of 5-LOX signaling molecules namely include, 5-HETE, LTB4, and cysteinyl LTs, which are well-known to initiate inf

• Nicotinamide In fact serotonin is a major modulator of

  2023-07-06

  

  In fact, serotonin is a major modulator of dopaminergic (DA) neuronal activity through the 5-HT2C receptor. Studies have shown that the selective 5-HT2C receptor agonist Ro60-0175 blocks the burst-firing of mesolimbic DA neurons, which project from the ventral tegmental area (VTA) to the nucleus acc

• TNF-alpha, recombinant murine protein receptor br Autophagy

  2023-07-05

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of TNF-alpha, recombinant murine protein receptor and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective st

• Neuropathic animals display increased sensitivity

  2023-07-05

  

  Neuropathic animals display increased sensitivity to the anti-nociceptive effect of baclofen and whilst the number and affinity of GABAB AR-C155858 synthesis in the dorsal horn are not altered (Smith et al., 1994; Zemoura et al., 2016), GABAB receptors subunits (B1 and B2) are both down-regulated in

• Compound was synthesized by reacting amino methoxybenzoate w

  2023-07-05

  

  Compound 31 was synthesized by reacting 5-amino-2-methoxybenzoate (28) with ethanesulfonyl chloride in the presence of pyridine in DCM to give sulfonamide 29. Hydrolysis of 29 by aqueous sodium hydroxide afforded the Tenatoprazole 30 which was converted to the acid chloride by heating in thionyl ch

• br Aromatase the key enzyme for estrogen formation

  2023-07-05

  

  Aromatase: the key enzyme for estrogen formation in adipose tissue Estrogens are synthesized from androgens by aromatase, a member of the cytochrome P450 superfamily, which is the rate-limiting enzyme in estrogen biosynthesis (Santen et al, 2009, Simpson et al, 1994). At the cellular level, aroma

• In order to determine whether the faster Rh induced

  2023-07-05

  

  In order to determine whether the faster Rh2-induced apoptosis is specific of cholesterol depletion, we determined the cytotoxic effect of Rh2 in cyclosporin depleted or not in sphingomyelin, another abundant plasma membrane lipid exhibiting enrichment in lipid rafts. We showed that, in contrast to

• To circumvent these issues multiple approaches have

  2023-07-05

  

  To circumvent these issues, multiple approaches have been developed that target small fractions of the genome, thus reducing the sequencing burden (Dostie et al., 2006; Fullwood et al., 2009; Mumbach et al., 2016). Application of one such approach, chromosome conformation capture carbon copy (5C), w

• The AT hook motif is highly conserved

  2023-07-05

  

  The AT-hook motif is highly conserved in evolution from bacteria to humans and is found in one or more copies in a large number of other, non-HMGA, proteins, many of which are transcription factors or are involved in chromatin remodeling [8]. For example, AT-hook peptide motifs are essential compone

• br Valsartan It is another ARB with several reports

  2023-07-05

  

  Valsartan It is another ARB, with several reports for its beneficial effects on CV system both in preclinical and clinical studies. Valsartan treatment has reduced the levels of pentraxin 3, a marker for inflammation and is well tolerated in terms of side effects [17]. In BSCORE study, 90-day sec

• br Materials and method br

  2023-07-05

  

  Materials and method Result and discussion Conclusion Acknowledgments This work is partly supported by the University Research Committee (URC) of the Senate of The Federal University of Technology, Akure. The authors thanked IFS for the funds (F/4449 1F and F/4449-2F) used to purchase th

• The finding that OCT is

  2023-07-05

  

  The finding that OCT3 is expressed in the nucleus accumbens (Gasser et al., 2009) suggests that inhibition of this transporter may underlie previously described effects of glucocorticoids on extracellular DA concentrations and indicates that DA clearance in this region is not mediated exclusively by

• A highly attenuated B pertussis strain named BPZE has recent

  2023-07-05

  

  A highly attenuated B. pertussis strain, named BPZE1, has recently been described [10]. It produces enzymatically inactive pertussis toxin (PT), no dermonecrotic toxin and only trace amounts of tracheal cytotoxin. Markedly reduced lung pathology was observed in mice intranasally (i.n.) infected with

11093 records 1/740 page Next 12345 下5页 Last page