• br Acknowledgement This work was supported by grant form EU

  2020-12-11

  

  Acknowledgement This work was supported by grant form EU (FP7 grant agreement no.: 266033 SPonge Enzyme End Cell for Innovative AppLication-SPECIAL). Introduction Prolyl 4-hydroxylases (P4Hs) have central roles in the synthesis of collagens and the regulation of oxygen homeostasis [1]. The po

• br Materials and methods br Results br

  2020-12-11

  

  Materials and methods Results Discussion Neointimal VSMC accumulation contributes considerably to vessel occlusion observed in both autologous vein graft degeneration [1], [2] and in-stent restenosis [26], [27]. In this study, the potential for retarding VSMC proliferation and hence amelior

• No orthologs could be found in our B

  2020-12-11

  

  No orthologs could be found in our B. oleracea BAC library for AtCk1/2, which could mean that it is unique to Arabidopsis, or that we failed to detect it in our library. However, the second possibility is unlikely considering that Southern blotting analysis with four restriction enzymes disclosed fr

• br Discussion The present results demonstrate

  2020-12-11

  

  Discussion The present results demonstrate that high dose estrogen–progestogen OC treatment produced impaired glucose tolerance and glucose tolerance was preserved during low dose estrogen–progestogen, high or low dose progestogen-only OC use. The study also shows that impaired glucose tolerance

• Amphiphilic compounds lower interfacial tension and its biol

  2020-12-11

  

  Amphiphilic compounds lower interfacial tension and its biological production often results in a competitive environmental advantage (Darvishi et al., 2011). The reduction of interfacial tension can increase the biologically available surface areas resulting in increased metabolism of insoluble comp

• The isomeric phenyloxazole not only exhibited increased pote

  2020-12-11

  

  The isomeric 5-phenyloxazole not only exhibited increased potency against NEP, but also a decreased ACE inhibition thus providing encouraging selectivity. Changing the P1 group from an -propyl to a more polar methoxyethyl at the left hand Oxamic acid (as seen in compound pairs – and –) decreased AC

• MicroRNA miRNA is a class of highly conserved non coding

  2020-12-10

  

  MicroRNA (miRNA) is a class of highly conserved, non-coding small molecules containing 19–25 nucleotides. miRNAs are involved in the regulation of genes associated with cancer development and progression and therefore can act as oncogenes, by contributing to tumor formation,17, 18 or as tumor suppre

• It was hypothesized that if modafinil acts primarily via

  2020-12-10

  

  It was hypothesized that if modafinil acts primarily via a noradrenergic mechanism, Dbh −/− mice should be non-responsive since they completely lack NE. In contrast, if modafinil acts mainly through DA systems, these mice should be hypersensitive. Modafinil was tested in Dbh −/− mice using both loco

• The nuclear receptor related protein Nurr NR

  2020-12-10

  

  The nuclear receptor related-1 protein, Nurr1 (NR4A2), is a transcription factor that regulates the orthovanadate of genes critical for the development, maintenance, and survival of dopaminergic neurons (Alavian et al., 2014, Decressac et al., 2013, Dong et al., 2016, Jankovic et al., 2005, Johnson

• Pol is responsible for the bulk of leading strand

  2020-12-10

  

  Pol ε is responsible for the bulk of leading-strand synthesis in vivo (Daigaku et al., 2015, Nick McElhinny et al., 2008, Pursell et al., 2007) and physically associates with CMG (Langston et al., 2014, Sengupta et al., 2013, Sun et al., 2015, Zhou et al., 2017). Furthermore, leading-strand synthesi

• It is conceivable however that the distortion induced by

  2020-12-10

  

  It is conceivable, however, that the distortion induced by adozelesin in dsDNA may decrease the processivity of the translocating RecBCD enzyme so that it dissociates more frequently from adducted DNA relative to unmodified DNA. Premature termination from the DNA would also produce partially unwound

• Many DNA repair pathways are candidates

  2020-12-10

  

  Many DNA repair pathways are candidates for DPC repair. Nucleotide excision repair (NER) is widely involved in both bacteria and eukaryotes in removing cross-linked protein with low molecular weights (11kDa) (Ide et al., 2011). The predominant pathway chosen by EDTA may also depend on the type of d

• br Discussion Electroporation is a convenient and efficient

  2020-12-10

  

  Discussion Electroporation is a convenient and efficient way to introduce foreign material into mglur antagonist [10], [16], [17], [18]. There are a lot of different protocols for transfection with electroporation. It was reported that there are several parameters that are relevant to successful

• br Type II NAD P

  2020-12-10

  

  Type II NAD(P)H Dehydrogenases in Fungi Fermentative YeastSaccharomyces cerevisiaeBecause S. cerevisiae is a facultative CP 31398 dihydrochloride yeast capable of meeting its energy requirements with ATP generated by fermentation, only relatively few mitochondrial proteins are essential for cell

• In order to assess quantitatively the contribution of the un

  2020-12-10

  

  In order to assess quantitatively the contribution of the ung, dug and dut Methscopolamine australia to uracil-DNA accumulation in E. coli, we have developed a novel method for measuring uracil residues in DNA that is based on the approach of Kow and co-workers [33] for measuring AP-sites in DNA. T

14616 records 664/975 page Previous Next First page 上5页 661662663664665 下5页 Last page