• Compound was generated using a literature procedure

  2021-04-17

  

  Compound was generated using a literature procedure and required two-step Dess–Martin-periodinane/Pinnick oxidation prior to the methylation of the sulfonamide. Compound () was obtained from the Suzuki coupling of the methyl ester intermediate (en route to ac 723 ). Hydrolysis of all methyl este

• In a cell based functional assay the antagonist

  2021-04-17

  

  In a cell-based functional assay, the antagonist properties of were assessed by measuring inhibition of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells. produced a concentration-dependent inhibition of CRF (1nM)-induced cAMP production with an IC

• The regression also revealed a significant association betwe

  2021-04-17

  

  The regression also revealed a significant association between admission selectivity (SELECT) and exam pass rate (PASS%) (p Calmidazolium chloride serve as an indicator of a student’s ability to learn and their aptitude for academic success. These same qualities likely enable more selective schools

• br Materials and methods br Results and discussion br Conclu

  2021-04-17

  

  Materials and methods Results and discussion Conclusions Given that the activity of anti-plant virus compounds is related to host tobacco, virus, and compounds, we determined the effect of anti-CMV compound NNM on defense enzyme activity and chlorophyll index in tobacco, and we used RIB as

• br Results and discussion The results and subgroup analysis

  2021-04-17

  

  Results and discussion The results and subgroup analysis of cholesterol and NCS from the both surveys are listed in Table 2 and shown in Fig. 1, A1 to E2. Common discussion Unlikely to the other NCS assays, a target value for cholesterol could be reported in the present survey. For NCS assays

• br Conclusions ERK and its phosphorylation

  2021-04-17

  

  Conclusions ERK 1/2 and its phosphorylation plays an essential role in the hippocampus and can be triggered by both ROS accumulation and excessive Ca2+. DBP exposure can also affect the production of ROS and Ca2+ in the hippocampus. The question therefore arises as to whether the cell injury or a

• E ligases provide substrate recognition specificity Ubiquiti

  2021-04-17

  

  E3 ligases provide substrate recognition specificity Ubiquitination KB SRC 4 australia and substrate specificity in mammals is achieved by the existence of over six-hundred E3-ubiquitin ligases that catalyze the final step of ubiquitination, compared with only one E1 and very few E2 enzymes known

• DNA replication checkpoint kinases in both yeast

  2021-04-17

  

  DNA replication checkpoint kinases in both yeast and human lpa receptor upregulate dNTP levels under replication stress to mediate their essential function at replication forks (Yeeles et al., 2013). It is possible that upregulation of dNTP levels under replication stress helps fork restart once re

• High throughput screening HTS of

  2021-04-17

  

  High throughput screening (HTS) of the AstraZeneca Piperlongumine collection was conducted and identified oxadiazole amide () originating from a kinase directed screening library (although inactive against a panel of kinases). This compound had moderate potency as a DGAT-1 inhibitor (IC=0.52μM) an

• tachykinin receptor It was demonstrated that the addition of

  2021-04-17

  

  It was demonstrated that the addition of 10-fold excess of α-synuclein without modifications (with respect to the molar concentration of tetrameric GAPDH) leads to partial inactivation of GAPDH after 1-h incubation by 20% (Fig. 4, curve 2) in tachykinin receptor to insignificant decrease of the spe

• Pyrazolopyrimidines are bioisostere of purine exhibit promis

  2021-04-17

  

  Pyrazolopyrimidines are bioisostere of purine exhibit promising antitumor activity by competitively binding to the ATP active site of different kinase HOAt [16,17]. Several compounds of this family were found to induce apoptosis and/or reduce cell proliferation in various solid tumour and leukaemia

• The pharmacokinetics properties of compound were

  2021-04-17

  

  The pharmacokinetics properties of compound were evaluated in male Sprague Dawley rats following IV (0.7mg/kg) and oral (2.0mg/kg) dosing. The total body clearance and the terminal half-life were 0.73 L/h/kg and 5.1h, respectively. After oral administration the compound showed good bioavailability (

• This work started from the

  2021-04-16

  

  This work started from the standard version of the CPA model [17] and investigated its known weaknesses: 1) not meeting the defined critical temperature, 2) missing the temperature dependence of pure component saturated liquid densities, 3) using an α function in the cubic term that can provide unre

• We performed three baseline scans in two baboons

  2021-04-16

  

  We performed three baseline scans in two baboons and one blocking study by administering 1 mg/kg (i.v) meloxicam 30 min prior to [C]TMI injection (injected activity 175.75 ± 18.5 MBq, mass of unlabeled TMI blood Cyclosporin H synthesis barrier (BBB) and retained in brain with a somewhat heterogeneo

• Tinnitus Met carriers with severe hearing

  2021-04-16

  

  Tinnitus Met carriers with severe hearing loss perceive their tinnitus as being louder, which is associated with increased activity in the PHC, increased PHC→pgACC connectivity, as well as decreased pgACC→PHC connectivity. This indicates that Met carriers with severe hearing loss have increased tinn

15357 records 642/1024 page Previous Next First page 上5页 641642643644645 下5页 Last page