• In the present study we

  2021-09-23

  

  In the present study, we found that the expression of GPR120 in decidua from women of spontaneous abortion was significantly downregulated compared to the decidua from that of normal pregnancy. Moreover, GPR120 deletion (GPR120−/−) or inhibition predisposed mice to LPS or RU486 induced abortion, ind

• Migratory properties of Treg are

  2021-09-23

  

  Migratory properties of Treg are extremely important for the potential in vivo application. Therefore, the observed expression of CXCR3 on almost all obtained insulin-specific Treg is crucial for directing Kif15-IN-1 into the inflamed tissue (in this case pancreatic islets). CXCR3 responds to CXCL9

• To determine the functional consequences of HIV gp binding

  2021-09-23

  

  To determine the functional consequences of HIV gp120 binding to vaginal epithelial cells, an annotation clustering of the differentially expressed genes was performed. The top enriched biological processes included an inflammatory immune response, defense response and the pathways included the SODD

• Milligan et al demonstrated the important role of

  2021-09-23

  

  Milligan et al. [31] demonstrated the important role of TNF-α, IL-6 and IL-1β in the development of mechanical hyperalgesia induced by intrathecal injection of gp120. Because of this work, we decide to produce and purify gp120 to develop biological systems to study pain and behavior in rodents. Intr

• br Materials and methods br

  2021-09-23

  

  Materials and methods Results and discussion We recently found that the GlyT1 N-terminal and C-terminal sequences could be modified by phophorylation, or partially lost under pathological conditions by calcium-dependent proteolysis (Baliova and Jursky, 2005, Baliova and Jursky, 2010). While re

• To shed more light on the binding of

  2021-09-23

  

  To shed more light on the binding of benzophenanthridine to GlyT1, we studied how the replacement of certain residues around the sanguinarine sensitive cysteine 475 previously identified (Jursky et al., 2012) affects GlyT1 inhibition of by these alkaloids. Based on these results we propose a putativ

• br Glycoengineering br The Omics

  2021-09-23

  

  Glycoengineering The « Omics » perspective The publication of the CHO-K1 genome sequence in 2011, followed by the publication of two Chinese hamster and six CHO cell line genomes in 2013, bring new opportunities in developing and engineering CHO Pasireotide for improved glycoprotein production

• Active compounds and were further tested and EC and pEC

  2021-09-23

  

  Active compounds , , and were further tested and EC and pEC values were determined as shown in . Compound showed EC of 0.97μM (pEC 6.01) with 84.5% maximal response, which suggests that introduction of alkyl chain on aromatic nucleus of , resulted in improved GPR40 agonistic activity than that of

• br Ligand binding free energies In order to

  2021-09-23

  

  Ligand-binding free energies In order to compute the absolute free factor xa inhibitors associated with binding a ligand to a flexible iGluR LBD, a theory that accounts for all the principal thermodynamic contributions from ligand docking and LBD closure had to be developed. This was accomplished

• The identification of distinct expression domains in

  2021-09-23

  

  The identification of distinct expression domains in the limb suggested that these domains might have specific biological functions. We explored this possibility by determining enriched biological processes for each category using GO ontology term analysis (WebGestalt) (Zhang et al., 2005). Category

• There is a dual inducer of both galanin and

  2021-09-23

  

  There is a dual inducer of both galanin and super-threshold pain. First, injury-induced pain may stimulate galanin secretion. After peripheral nerve injury, the galanin expression level was upregulated in dorsal root ganglion (DRG), dorsal horn and hypothalamic arcuate of rats [25], [28], [33]. The

• br Materials and methods br Results br Discussion

  2021-09-23

  

  Materials and methods Results Discussion Although homologues of the β-galactosidase gene were known to exist in the Xenopus genome, and SA-β-gal activity has been detected in whole-mount Xenopus embryos by histochemical staining (Davaapil et al., 2017), no reports have been presented so far

• Furthermore rs is the one which is

  2021-09-22

  

  Furthermore, rs17171119 is the one which is studied well so far. One of the earlier studies has reported the clinical outcome and impact of EZH2 SNPs (rs41277434, rs3757441, rs2302427 rs9177211 T> C) (Crea et al., 2012). The only coding SNP ID rs2302427 has been studied in various diseases such as h

• Some SNPs have been identified for HRH in

  2021-09-22

  

  Some SNPs have been identified for HRH in cancer (Table 4). Looking into breast cancer research, H4 receptor polymorphisms have been recently associated with the malignancy of the disease. This was evidenced upon the analysis of genotypes and haplotypes of a Chinese Han population; this study showed

• br Materials and methods br Results To examine the time

  2021-09-22

  

  Materials and methods Results To examine the time and organ specific effect of normal photoperiod and dark environment on the ANP (1-11), rat of different SlHXKs and on the enzyme activities, these parameters were determined in different leaf positions of tomato plants. Under control condition

14593 records 501/973 page Previous Next First page 上5页 501502503504505 下5页 Last page