• Many studies have used paradigms based

  2021-05-13

  

  Many studies have used paradigms based on animal models to understand human emotional behavior because it appears to be correlated with fear- and anxiety-related defensive patterns in non-human mammals (Blanchard et al., 2001). In this case, defensive reactions are used to study the neural substrate

• The use of AACSB accreditation as an indicator of

  2021-05-13

  

  The use of AACSB accreditation as an indicator of expected performance on the CPA exam has been examined by prior studies (e.g. Barilla et al., 2008, Boone et al., 2006, Grant et al., 2002, Howell and Heshizer, 2006, Lindsay and Campbell, 2003, Marts et al., 1998). While these studies are based on d

• Information on the mechanism by which parasite

  2021-05-12

  

  Information on the mechanism by which parasite infections promote ECM degradation is limited (McKerrow et al., 1983; Andrade, 1994; Lu and Lai, 2013; Thibeaux et al., 2014). The interaction of plasminogen-plasmin with proteins of microorganisms, including bacteria, has been suggested to play a key r

• br Methods br Results br Discussion Here we have

  2021-05-12

  

  Methods Results Discussion Here we have shown that two GPCR subtypes thought to trigger similar signalling events by coupling to Gαq in fact regulate different signalling networks via coupling to distinct G proteins. Thus global effects regulated by both receptors in events such as cardiac

• The role of activation of xenosensor

  2021-05-12

  

  The role of activation of xenosensor nuclear receptors such as PPARα, CAR, and PXR in producing hepatomegaly and liver tumors in rodents has been well-established (Klaunig et al., 2003, Lake, 2009). In the case of PPARα, the increase in liver weight results from increased peroxisomal mass and expans

• Given its high frequency it is not surprising that different

  2021-05-12

  

  Given its high frequency, it is not surprising that different strategies have been developed to restore the sensitivity of EGFR T790M-mutant PF 1022A to EGFR inhibition. To date, several different strategies have been evaluated in both preclinical and clinical models, but only few have been proved

• HCV has evolved mechanisms to evade humoral

  2021-05-12

  

  HCV has evolved mechanisms to evade humoral immune responses including high functional flexibility and variability of immunogenic portions of its envelope proteins. The highest sequence variability occurs in the first 27 Bezafibrate of the N-terminus of E2, which is referred to as the hypervariable

• br Results and discussion br Conclusion We have constructed

  2021-05-12

  

  Results and discussion Conclusion We have constructed a series of potent and greatly selective DPP-4 inhibitors with pyrazolo[1,5-a]pyrimidin-7(4H)-one core surrogates. The modification of the core led us to b2 which has IC50 of 80 nM and > 1000 fold selectivity over DPP-8 and DPP-9. We utiliz

• A potential weakness of the

  2021-05-12

  

  A potential weakness of the present study is that it involved population controls rather than family controls, which are a better way of controlling the effects of population stratification (e.g. ethnic group differences in allele frequencies). On the other hand, general population samples do have t

• Nanocomposite films with a GNP DNA filler

  2021-05-12

  

  Nanocomposite films with a GNP-DNA filler concentration of 20 wt%, 30 wt%, and 40 wt% were investigated by electrical impedance spectroscopy before and after UV-C irradiation (Fig. 2). EIS data were fitted to a RC-circuit model and surface resistivity values were calculated from the fitted resistanc

• Studies of Jelski and Szmitkowski show that

  2021-05-12

  

  Studies of Jelski and Szmitkowski show that differences of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity between tyrosine kinase receptor of many cancers and healthy tissue may be one of the factors intensifying carcinogenesis [7]. Moreover, changes of ADH and ALDH activity

• Reports on the participation of NDH

  2021-05-12

  

  Reports on the participation of NDH2 along with other respiratory complexes in the formation of a large supercomplex (Grandier-Vazeille et al. 2001) or even a respirosome-like structure in S. cerevisiae mitochondria (Matus-Ortega et al. 2015) are very intriguing. Similarly, in Y. lypolytica mitochon

• The absorption rate of polyphenols into the

  2021-05-12

  

  The DCG IV rate of polyphenols into the body is usually low. For example, the absorption rate of epigallocatechin gallate (EGCG), an active component in GP, is approximately 1% (Chen et al., 1997). To increase absorption of GP in the body, people have been increasing their intake of functional foods

• Previous studies on the chemokines

  2021-05-12

  

  Previous studies on the chemokines role in depression are not detailed enough, and cannot sufficiently demonstrate even a hypothetical mechanism explaining the differences in levels of particular chemokines and their receptors, in relation to the severity of depression [29], [30]. Previous studies o

• In this study for the first time we

  2021-05-12

  

  In this SNS-314 Mesylate study, for the first time, we demonstrated that herb-derived LFS-01 induces concomitant mitophagy and apoptosis in lymphoma cells. Through various biochemical studies, we showed that LFS-01 directly targets the sulfhydryl (-SH) group of a conserved cysteine in the nuclear e

11166 records 348/745 page Previous Next First page 上5页 346347348349350 下5页 Last page