• About three weeks later the

  2023-03-01

  

  About three weeks later, the patient visited our outpatient clinic complaining of gingival bleeding and pus discharge. In clinical examination bone exposure was observed in both mandibular posterior regions and bone necrosis had developed surrounding the #35=37 and 46, 47 implants installed 6 years

• lxr agonists It has been known for a while that oxygenation

  2023-03-01

  

  It has been known for a while that oxygenation (the addition of oxygen) of Aβ can inhibit the formation of amyloids and diminish their cytotoxicity. Photo-oxygenation of Aβ started with fullerenes almost a decade ago by Toshima and co-workers. Later, porphyrins and polyoxometalates were used as well

• br Experimental section br Introduction NMDA receptor induce

  2023-03-01

  

  Experimental section Introduction NMDA receptor-induced increases in AMPAR trafficking to the synaptic surface mediates changes in synaptic efficacy in a number of tepotinib receptor regions (Shi et al., 1999, Sun et al., 2005, Frenkel et al., 2006). While this process has been linked to the

• br Experimental section br Introduction Microglia were disco

  2023-03-01

  

  Experimental section Introduction Microglia were discovered as a novel cell population in Imatinib in 1933 by a Spanish physician and histologist Pío del Río-Hortega [1]. In the eye, scientists used Hortega's staining technique to label the microglia in the retinal outer plexiform layer (OPL)

• Decrease in soluble protein content in diabetic lenses

  2023-03-01

  

  Decrease in soluble protein content in diabetic lenses compared with those in control lenses in present study could be due to leakage of proteins and insolubilization. T. purpurea treatment could increase the levels of soluble proteins in diabetic lenses may be by preventing cross-linking/aggregatio

• br Disclosures br Author contributions

  2023-03-01

  

  Disclosures Author contributions Grants This work was supported by National Institutes of Health/National Heart, Lung, and Blood Institute MERIT Award R37 HL040696 to J.A.F. Acknowledgments Introduction The AGC kinases, named after the protein A, G and C kinases, are an evolutionaril

• Young disease transitioning B Sle mice show partial

  2023-03-01

  

  Young disease-transitioning B6·Sle1 mice show partial loss of leukocyte Axl versus B6 controls (data not shown). Further, BMDM from diseased B6·Sle1.Yaa mice do not express detectable levels of ADAM10 and TACE (ADAM17) but do express basal levels of Axl similar to wild type B6-derived BMDM (Suppleme

• br Materials and methods br

  2023-03-01

  

  Materials and methods Results Discussion The success of CAR-T cell therapy is based on two major facts: one is that cancer cells express tumor-associated antigens (TAAs) on their surface that can be detected by the human immune system; the other is that the CAR molecules target these TAAs o

• Reactive oxygen species is an aspect of

  2023-02-25

  

  Reactive oxygen species is an aspect of oxidative stress which are associated with many diseases such as rheumatoid arthritis, diabetes, inflammation, atherosclerosis and cancers (Collins, 2005; Halliwell, 1994). Thus, the need for naturally occurring antioxidants is of crucial importance. Some biop

• In recent years the higher lipophilicity thus better perform

  2023-02-25

  

  In recent years, the ‘higher lipophilicity’-thus-‘better performance’ tenet, derived from the polar paradox theory applied to micro-structured media, was challenged by novel and unexpected experimental results. In particular, the synthesis of many complete series of fatty L-AP5 esters of natural an

• br Conclusions br Funding This work was

  2023-02-25

  

  Conclusions Funding This work was supported by a Finnish government subsidy for health science research [grant numbers TYH2012141, TYH 2013218, and TYH 2014216]; the SSAC Foundation [grant numbers SLS-504141 and SLS-693781]; and the Paulo Foundation. The funding sources had no involvement in s

• br HIF Signaling in AA Therapy Resistance

  2023-02-25

  

  HIF-α Signaling in AA Therapy Resistance An important result emerging from Phase 3 clinical trials testing AA therapies is improvement of progression-free survival (PFS) that is not accompanied by enhanced overall survival (OS) [26]. This dichotomy has been attributed to mechanisms of acquired re

• In the current investigation we studied

  2023-02-25

  

  In the current investigation, we studied the effect of propofol on prostate cancer cells. Propofol is one of the most commonly used drugs in the critical care setting and for the induction of general anesthesia and moderate and deep sedation intraoperatively. Recent studies indicated that propofol e

• Nitrendipine receptor The first and the best characterized m

  2023-02-25

  

  The first and the best-characterized mechanism of receptor-dependent internalization of Aβ is mediated via the α7-nicotinic Nitrendipine receptor receptor [82]. Lipoprotein receptor protein represents the second best-studied route that facilitates the uptake of Aβ by neurons, involving additional m

• br Acknowledgments and Disclosures br

  2023-02-25

  

  Acknowledgments and Disclosures Introduction Over the last decade, the most visible strategy for the treatment of Alzheimer's disease (AD) has been amyloid β peptide (Aβ) immunotherapy (reviewed in [1]). Although the first efforts with Aβ immunotherapy failed to complete clinical trials [1], A

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