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Ginger derived glycoproteins contain a variety of
2021-11-15

Ginger-derived SB-334867 free base contain a variety of functional components, including specific phenolic compounds, purine compounds, and bioactive polysaccharides. Moreover, glycoproteins belong to the glycoconjugates, which combine some of the properties of polysaccharides and proteins. It has
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In the present study compared to diabetic
2021-11-15

In the present study, compared to diabetic control rats, hepatic glucose-6-phosphatase activity was significantly decreased in both SE and METF treated diabetic animals, with the latter producing greater reduction in glucose-6-phosphatase activity. This observation is consistent with the claim of Ta
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br Therapeutic approaches exploiting Cx function
2021-11-15

Therapeutic approaches exploiting Cx43 function Due to their potential role in cancer metastasis, attempts have been made to alter connexin function to inhibit cancer growth. Therapeutic approaches include Cx43 peptide mimetics, Cx43 inhibitors, chemical agents capable of enhancing Cx43 function,
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Following optimization chemicals which were considered
2021-11-15

Following optimization, 31 chemicals, which were considered as the skin sensitizers and non-sensitizers in LLNA studies, were studied for their potential of β-galactosidase suppression (Table 2). The detailed information on test chemicals used were given in Table 1. With optimum cell densities, E. c
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Recently accumulated evidence has revealed a close link
2021-11-15

Recently, accumulated evidence has revealed a close link of FXR to gluconeogenesis. For example, activation of FXR by its agonist GW4064 improved hyperglycemia in db/db mice by repressing gluconeogenesis [15], and FXR agonist CDCA decreased transactivation activity of key gluconeogenic genes by indu
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br Materials methods br Results FAS c AA AG
2021-11-15

Materials & methods Results FAS c.-671AA, AG and GG genotypes and A and G 5α-dihydro-11-keto Testosterone mg frequencies were similar in both patients with FMF and healthy control groups, and no significant difference was found (P>0.05, Table 1). The frequency of TC genotype in FASLG in the h
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Daun02 br Introduction More than structurally different isop
2021-11-15

Introduction More than 30,000 structurally different isoprenoids, such as steroids, carotenoids, prenyl side-chain of quinones, prenyl proteins, and natural rubber, exist in nature. In a biosynthetic pathway, linear prenyl diphosphates are common structures as a precursor of isoprenoids, as shown
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In studies described earlier IRL was administered intravenou
2021-11-15

In studies described earlier, IRL-1620 was administered intravenously; however, because of its short half-life (Rubin and Levin, 1994) (about 7–8min), the dosing had to be repeated three times. Also, a dose-dependent hypotension was observed with repeated doses of IRL-1620 in rats (Leonard and Gulat
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Ciprofloxacin hydrochloride Computational approaches such as
2021-11-15

Computational approaches such as docking and classical molecular dynamics (MD) are now commonly used to study the structure and dynamics of proteins as well as associated protein-ligand interactions [12]. A fundamental requirement of MD in order to accurately determine the behavior of a protein over
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In this paper we demonstrate a diatomaceous earth based TLC
2021-11-15

In this paper, we demonstrate a Phloretin based TLC-SERS sensing technique combined with machine learning analysis to quantitatively detect seafood allergen in real spoiled tuna samples. We fabricate a diatomaceous earth TLC plate as a separable SERS-active substrate to detect histamine in artifici
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Myocardial growth and maturation is
2021-11-15

Myocardial growth and maturation is regulated in part by signals from the underlying endocardium (Brutsaert, 2003, de la Pompa and Epstein, 2012, Rentschler et al., 2010). More generally, endothelial cetp inhibitor play an increasingly appreciated role in instructing organogenesis by providing induc
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br Acknowledgements and disclosures This
2021-11-15

Acknowledgements and disclosures This work was supported in part by the National Institutes of Health (R01 HL-131673-01A1) and the Veterans Administration (BX-002539-01), United States. The authors have nothing to disclose concerning any conflict of interest. Introduction Adaptations are ofte
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br Conflict of interest br Introduction Endometriosis is def
2021-11-15

Conflict of interest Introduction Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus, most often in the pelvic peritoneum and ovaries. This disorder affects an estimated 10% of women in the reproductive age group and is basically an estrogen-dependent
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Hh signaling pathway plays an essential role
2021-11-15

Hh signaling pathway plays an essential role in the regulation of invertebrate and vertebrate tissue development and metabolic homeostasis. Components of Hh signaling pathway have been identified in succession, including Hh ligands, membrane protein receptors, cytoplasmic components and transcriptio
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Although it is currently unknown why the longer splice varia
2021-11-12

Although it is currently unknown why the longer splice variant found in the human has not been found in any other species, similar results have been reported for other receptors, including the Temozolomide receptor splice variant ERbeta2 identified in human and primate, but not other species (Siere
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